The Effects of Dexmedetomidine on cTnI and GP-BB in Patients Undergoing OPCABG

General Hospital of Ningxia Medical University

Status: Unknown

Conditions: Coronary Artery Bypass, Off-Pump

Treatments: Other: normal saline; Drug: dexmedetomidine

Study type: Interventional

Funder types: Other

Identifiers

NCT03163693

2015-NW-028

Details and patient eligibility

About

The purpose of this study is to observe the impact of dexmedetomidine on Cardiac Troponin I and Glycogen Phosphorylase Isoenzyme BB in patients undergoing off-pump coronary artery bypass Grafting.

Full description

Dexmedetomidine is a highly selective α2-adrenoceptor agonist used as a sedative or adjuvant anesthetic drug in clinical settings.From clinical observation, dexmedetomidine has been revealed to reduce the incidence of cardiovascular adverse events in patients with heart diseases during non-cardiac surgeries.Therefore, the aim of this sudy is to observe the impact of dexmedetomidine on Cardiac Troponin I and Glycogen Phosphorylase Isoenzyme BB in patients during cardiac surgeries.

Enrollment: 40 patients

Sex: All

Ages: 40 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing off - pump coronary artery bypass grafting
• ASA physical status III-IV
• Aged 40-70 years
• NYHA physical status II-III

Exclusion criteria

• Bradycardia
• Atrioventricular block
• Echocardiography suggested:LVEF <40%, LVED>65mm
• Allergic to the drugs

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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40 participants in 2 patient groups, including a placebo group

Group dexmedetomidine

Experimental group

Description:

20 eligible patients are received 0.5ug/kg dexmedetomidine intravenously 15 minutes before surgery

Treatment:

Drug: dexmedetomidine

Group control

Placebo Comparator group

Description:

20 eligible patients are received equal volumes normal saline intravenously 15 minutes before surgery

Treatment:

Other: normal saline