The Effects of Dexmedetomidine on Postoperative Cognitive Function in Open Heart Surgery

Sohag University

Status: Enrolling

Conditions: Neuronal Damage; Open Heart Sugery

Treatments: Drug: Dexmedetomidine

Study type: Interventional

Funder types: Other

Identifiers

NCT06655025

Soh-Med-15-10-1MD

Details and patient eligibility

About

To assess the impact of Dexmedetomidine on postoperative cognitive function and serum Neuron Specific Enolase levels as an indicator of neuronal injury in patients undergoing open heart surgery

Enrollment: 32 estimated patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients of both sexes undergoing elective open-heart surgery

Exclusion criteria

• Patients with a history of neurological disorders, severe renal or liver dysfunction, or contraindications to Dexmedetomidine as in patients with known QT prolongation, a history of other arrhythmias, symptomatic bradycardia, hypokalemia, or hypomagnesemia, and in patients receiving other drugs known to prolong the QT interval.

Patients with cognitive impairment, mental and psychological illness and chronic alcoholics, drug addicts, abuse of psychotropic substances, illiterate education

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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32 participants in 2 patient groups, including a placebo group

Group B (Dexmedetomidine)

Active Comparator group

Description:

Dexmedetomidine infusion

Treatment:

Drug: Dexmedetomidine

Group A (control)

Placebo Comparator group

Description:

normal saline infusion

Treatment:

Drug: Dexmedetomidine