The Effects of Different Anesthesia Methods on Perioperative Neurocognitive Disorders in the Elderly

Shenzhen University

Status: Enrolling

Conditions: PND

Treatments: Device: spinal anesthesia; Device: nerve block combined with general anesthesia

Study type: Interventional

Funder types: Other

Identifiers

NCT04488952

20193357001-XZ01

Details and patient eligibility

About

Perioperative Neurocognitive Disorders(PND) is a common perioperative complication among the elderly, especially in the plastic surgery. Different anesthesia methods have different incidences of PND, but it's still unknow which is better between spinal anesthesia and nerve block combined with general anesthesia. We will apply a psychometric battery test which contain different cognitive domains to estimate the incidence of PND at a week a month and a year after surgery with different anesthesia methods. Study has showed that functional magnetic resonance imaging (fMRI) could detect a cognitive decline through spontaneous neuronal activity in the cortex and hippocampus. In our study, multi-mode imaging technology is used to conduct in-depth research on MRI and make correlation analysis with cognitive function.

Enrollment: 350 estimated patients

Sex: All

Ages: 60 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• aged 60-85years
• ASA I-III
• Received elective surgery of unilateral lower extremity orthopedics
• The anesthesia lasted more than 2 hours

Exclusion criteria

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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350 participants in 3 patient groups, including a placebo group

nerve block combined with general anesthesia group

Experimental group

Description:

Patients in this group receive nerve block combined with general anesthesia.

Treatment:

Device: nerve block combined with general anesthesia

Device: spinal anesthesia

spinal anesthesia group

Experimental group

Description:

Patients in this group receive spinal anesthesia.

Treatment:

Device: nerve block combined with general anesthesia

Device: spinal anesthesia

control group

Placebo Comparator group

Description:

This group is used to obtain the learning effect.

Treatment:

Device: nerve block combined with general anesthesia

Device: spinal anesthesia