The Effects of Different Clonidine Concentrations on Axillary Brachial Plexus Block With 1,5% Lidocaine

Universidade Federal do Rio de Janeiro

Status and phase: Completed; Phase 2

Conditions: Fascicular Block; Latency Period; Pain, Postoperative; Motor Activity

Treatments: Drug: Lidocaine 40 ml; Drug: high Clonidine concentration; Drug: low clonidine concentration; Drug: Lidocaine

Study type: Interventional

Funder types: Other

Identifiers

NCT01620112

090/2002

Details and patient eligibility

About

The purpose of this study is to determine whether different clonidine concentration on axillary brachial plexus block with 1,5% lidocaine for upper limb surgery may influence the sensory and motor block onset time and duration, postoperative analgesia duration, postoperative pain intensity

Full description

Brachial plexus blocks are frequently used in surgical procedures involving the upper limb because they facilitate surgical anaesthesia, muscle relaxation and post-operative analgesics.

Various drugs are used to supplement local anaesthetics during brachial plexus block. Many studies in the literature show that clonidine, which is an alpha-2 agonist, prolongs the length of anesthesia and post-operative analgesia.4,5 However, clonidine's side effects-such as hypotension, bradycardia and sedation can limit its use.

There are no studies comparing different clonidine concentrations on the axillary brachial block, so the hypothesis of the present study was that different clonidine concentrations and LA volumes may influence the anaesthesia and analgesia quality on this type of regional block.

Enrollment: 60 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• both genders,
• over 18 years old,
• American Society of Anesthesiologists (ASA) 1 to 3

Exclusion criteria

• patients with chronic use of analgesics and non-steroidal anti-inflammatories drugs,
• pregnant,
• with infection at the puncture site,
• coagulopathies or intolerance to drugs used in the study

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 4 patient groups

low clonidine concentration

Active Comparator group

Description:

clonidine concentration 1 ml on 40 ml of lidocaine 1.5% for upper brachial plexus

Treatment:

Drug: low clonidine concentration

lidocaine 20 ml 1,5%

Active Comparator group

Description:

lidocaine 20 ml 1,5% without clonidine for axillary brachial plexus block for upper limb surgery

Treatment:

Drug: Lidocaine

high clonidine concentration

Active Comparator group

Description:

clonidine concentration 150 mcg on 20 ml of lidocaine 1,5% for upper brachial plexus

Treatment:

Drug: high Clonidine concentration

40 ml lidocaine 1,5%

Active Comparator group

Description:

40 ml of lidocaine 1,5% without clonidine for upper brachial plexus

Treatment:

Drug: Lidocaine 40 ml