The Effects of Different Flow Settings on Lung Impedance

Rush

Status: Completed

Conditions: Healthy

Treatments: Device: High-flow nasal cannula device with flow setting at 40 L/min or higher

Study type: Interventional

Funder types: Other

Identifiers

NCT06228703

HFNC-05

Details and patient eligibility

About

This prospective, randomized crossover trial will enroll adult healthy volunteers. Initially, the subject's peak inspiratory flow will be measured using a mask connected with a respiratory monitor. Subsequently, the volunteers will undergo HFNC treatment at different flow settings while their peak inspiratory flow will be continuously monitored. The primary outcome of this study is the lung aeration with different flow settings. Secondary outcomes include the lung aeration with different devices, subject's comfort at different flow settings, and the correlation between the subject's peak inspiratory flow measured by HFNC and by a mask connected with a respiratory monitor.

Full description

Background: High-flow nasal cannula (HFNC) is a device that can reduce the work of breathing (WOB) and improve oxygenation by providing a flow that matches or exceeds patient's peak inspiratory flow during tidal breathing. Despite its widespread use, there remains a lack of consensus regarding the optimal flow settings. Two new HFNC devices that can provide information regarding patient's peak tidal inspiratory flow breath by breath are recently available, which might help guide set and titrate the flow settings. This study aims to investigate the effects of different flow settings on lung impedance in a cohort of healthy volunteers by using the two new HFNC devices.

Methods: This prospective, randomized crossover trial will enroll adult healthy volunteers. Initially, the subject's peak inspiratory flow will be measured using a mask connected with a respiratory monitor. Subsequently, the volunteers will undergo HFNC treatment at different flow settings while their peak inspiratory flow will be continuously monitored. The primary outcome of this study is the lung aeration with different flow settings. Secondary outcomes include the lung aeration with different devices, subject's comfort at different flow settings, and the correlation between the subject's peak inspiratory flow measured by HFNC and by a mask connected with a respiratory monitor.

Enrollment: 26 patients

Sex: All

Ages: 21 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy volunteers between 21-65 years old

Exclusion criteria

• Chronic pulmonary diseases, including COPD, interstitial lung disease, cystic fibrosis, etc.
• Uncontrolled asthma;
• Pregnancy
• Subjects who have cold/flu symptoms (sore throat, runny nose, fever, chills, coughing)
• Nose abnormalities that can affect the functionality of the nasal prongs

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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26 participants in 6 patient groups

Airvo 3 high-flow nasal cannula device with flow set at 20 L/min

No Intervention group

Description:

A new high-flow nasal cannula device (Airvo 3) will be used in the study, with the flow set at 20 L/min

HFT 750 high-flow nasal cannula device with flow set at 20 L/min

No Intervention group

Description:

A new high-flow nasal cannula device (HFT 750) will be used in the study, with the flow set at 20 L/min

Airvo 3 high-flow nasal cannula device with flow set at 40 L/min

Experimental group

Description:

Airvo 3 will be used with the flow set at 40 L/min

Treatment:

Device: High-flow nasal cannula device with flow setting at 40 L/min or higher

Airvo 3 high-flow nasal cannula device with flow set at 60 L/min

Experimental group

Description:

Airvo 3 will be used with the flow set at 60 L/min

Treatment:

Device: High-flow nasal cannula device with flow setting at 40 L/min or higher

HFT 750 high-flow nasal cannula device with flow set at 40 L/min

Experimental group

Description:

HFT 750 will be used with the flow set at 40 L/min

Treatment:

Device: High-flow nasal cannula device with flow setting at 40 L/min or higher

HFT 750 high-flow nasal cannula device with flow set at 60 L/min

Experimental group

Description:

HFT 750 will be used with the flow set at 60 L/min

Treatment:

Device: High-flow nasal cannula device with flow setting at 40 L/min or higher