The Effects of Dobutamine on Postoperative Cardiac Function in Aortic Valve Replacement

University of Aarhus

Status and phase: Suspended; Phase 4

Conditions: Heart Failure

Treatments: Drug: Dobutamine

Study type: Interventional

Funder types: Other

Identifiers

NCT01375335

1818

Details and patient eligibility

About

The use of dobutamine in postoperative hemodynamic treatment is widespread despite seemingly intact contraction of the heart. This study aims to elucidate the efficacy of low-dose dobutamine infusion in patients in the postoperative phase replacement of the aortic valve.

Enrollment: 10 estimated patients

Sex: All

Ages: 19 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18-90 years
• Left ventricular posterior wall =/>12mm
• Ejection fraction > 45%
• Sinus rhythm
• Eligible for aortic valve replacement

Exclusion criteria

• Need for concomitant cardiac bypass operation.
• Moderate or severe insufficiency of the mitral valve
• Active endocarditis
• Insufficient ultrasound window
• Using B-blockers
• Liver insufficiency
• Patients treated with COMT-inhibitors
• Allergy towards dobutamine
• Pregnancy
• Women of fertile age who do not use relevant anti-conception
• Lacking participant consent

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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10 participants in 1 patient group

Dobutamine

Experimental group

Treatment:

Drug: Dobutamine