The Effects of Early Enteral Nutrition on Endoscopic Therapy of Esophagogastric Varices in Liver Cirrhosis

Shandong University

Status: Completed

Conditions: Liver Cirrhosis; Esophageal and Gastric Varices

Treatments: Dietary Supplement: nutrient solution

Study type: Observational

Funder types: Other

Identifiers

NCT04823780

20200901-Qilu

Details and patient eligibility

About

The purpose of this study was to evaluate the safety of early enteral nutrition on endoscopic therapy of esophagogastric varices in Liver Cirrhosis ,and to assess the impact of different eating times on patients, so as to determine the best time for patients to obtain nutrition after surgery.

Full description

For patients with gastroesophageal varices in Liver Cirrhosis,, there is no clear guideline and consensus on when to start eating after endoscopic treatment. In 2015, a randomized controlled study in Taiwan of China confirmed that compared with liquid diet given 48 h after endoscopic treatment, liquid diet given 4 h and started enteral nutrition would not increase the risk of rebleeding, and could improve the nutritional status of patients. However, some patients after endoscopic treatment would suffer from post-sternal pain, abdominal pain, nausea, vomiting and other discomforts, affecting appetite and delay the diet time. Based on the above research background, we observed and evaluated the safety and effectiveness of early enteral nutrition in patients with cirrhotic esophageal and gastric varices after endoscopic treatment, and analyzed the influencing factors of enteral nutrition in patients with cirrhotic esophageal and gastric varices after endoscopic treatment, so as to further clarify the optimal time for patients to eat after endoscopic treatment.

Enrollment: 397 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with cirrhosis of gastroesophageal varices undergoing endoscopic therapy

Exclusion criteria

• Endoscopic treatment of uncontrollable bleeding
• Accompanied with other endoscopic treatments that need to be fasting
• With obvious hepatic encephalopathy and liver failure
• Did not sign the informed consent form and refused to participate

Trial design

397 participants in 2 patient groups

early enteral nutrition support group

Description:

Nutrient solution is provided through oral nutrient solution within 4-48 hours after endoscopic treatment

Treatment:

Dietary Supplement: nutrient solution

parenteral Nutrition Group

Description:

Intravenous nutrition is provided within 48 hours after endoscopic treatment