The Effects of Early vs. Delayed Time-Restricted Eating on Metabolic Syndrome Parameters

SINEM BAYRAM

Status: Completed

Conditions: Obesity and Metabolic Syndrome

Treatments: Behavioral: Delayed Time Restricted Eating with calorie restriction; Behavioral: Control group with calorie restriction; Behavioral: Early time restricted eating with calorie restriction

Study type: Interventional

Funder types: Other

Identifiers

NCT07096505

SINEM_TRE_2025

KA23/107 (Other Identifier)

Details and patient eligibility

About

This study aims to compare the effects of early and delayed time-restricted eating on metabolic syndrome parameters in obese women.

Full description

This randomized controlled trial investigates the effects of time-restricted eating with different timing windows on metabolic syndrome parameters. A total of 36 sedentary obese women aged between 20-49 years were randomly assigned to one of three groups: Early Time-Restricted Eating (eTRE; 08:00-16:00), Delayed Time-Restricted Eating (dTRE; 12:00-20:00), and a Control group (08:00-20:00). Participants' physical activity levels were assessed using a one-day physical activity log. Total energy expenditure was calculated, and a 25% energy restriction was applied to create individualized medical nutrition therapy. Anthropometric measurements, body composition, and biochemical parameters were collected before and after the 8-week intervention.

Enrollment: 36 patients

Sex: Female

Ages: 20 to 49 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI > 30 kg/m²
• Able to follow dietary protocols
• No chronic disease (T1DM, T2DM, cardiovascular disease, cancer)
• Not on a weight loss diet in the past 6 months
• No psychiatric disorder
• Sedentary lifestyle

Exclusion criteria

• Menopausal women
• Cardiovascular disease
• Type 1 or Type 2 Diabetes
• Use of weight loss medications
• Pregnant or breastfeeding
• Smoking
• Shift workers

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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36 participants in 3 patient groups

Early Time-Restricted Eating with Calorie Restriction

Experimental group

Description:

Participants ate all meals between 08:00 and 16:00 daily with calorie restriction diet for 8 weeks.

Treatment:

Behavioral: Early time restricted eating with calorie restriction

Delayed Time-Restricted Eating with Calorie Restriction

Experimental group

Description:

Participants ate all meals between 12:00 and 20:00 daily with calorie restriction diet for 8 weeks.

Treatment:

Behavioral: Delayed Time Restricted Eating with calorie restriction

control

Active Comparator group

Description:

Participants ate all meals between 08:00 and 20:00 daily with calorie restriction diet for 8 weeks.

Treatment:

Behavioral: Control group with calorie restriction