The Effects of Endotracheal Suctioning on Pain and Serum Markers

Loma Linda University (LLU)

Status: Enrolling

Conditions: Adult; Uric Acid; Oxidative Stress; Pain Measurement; Mechanical Ventilation; Intubation; Sepsis; Influenza; COVID; Critical Illness; Hypoxia; Intensive Care Unit ICU; Pneumonia; Biomarkers / Blood; Pain, Procedural

Treatments: Procedure: endotracheal tube suctioning

Study type: Interventional

Funder types: Other

Identifiers

NCT06692400

5240556

Details and patient eligibility

About

The goal of this experimental study is to understand if endotracheal tube (ETT) suctioning increases pain and causes stress on the body in intubated adult ICU patients. These patients are already on ventilators, which means they need suctioning to keep their airways clear, but this procedure may be uncomfortable and cause stress.

The main questions this study aims to answer are:

Does ETT suctioning raise pain levels as measured by the Critical-Care Pain Observation Tool (CPOT)? Does ETT suctioning increase certain chemicals in the blood (hypoxanthine, xanthine, and uric acid) that show stress and lack of oxygen in the body? Researchers will compare patients who have ETT suctioning (intervention group) with those who do not have suctioning during the study period (control group) to see if there are differences in pain and blood markers of stress.

Participants will:

Have pain measured before and after suctioning using the CPOT. Have blood samples taken from an existing line at three time points: 5 minutes before, 5 minutes after, and 30 minutes after suctioning.

Provide demographic information (like age, gender, and diagnosis) from medical records.

This research will help improve how pain is managed for ICU patients who cannot speak for themselves, potentially leading to better pain relief methods in the future.

Enrollment: 110 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults (aged 18 years and older)
• Current diagnosis of flu, pneumonia, COVID, or sepsis
• Intubated and receiving mechanical ventilation.
• Have arterial lines placed
• Require endotracheal suctioning as part of their care

Exclusion criteria

• Patients receiving neuromuscular blocking agents
• Contraindications for blood draws (hemoglobin levels below 8.0 g/dL; Jehovah's Witness)

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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110 participants in 2 patient groups

Participants who undergo endotracheal tube (ETT) suctioning.

Experimental group

Description:

Participants will receive ETT suctioning as part of routine care.

Treatment:

Procedure: endotracheal tube suctioning

Participants who do not undergo ETT suctioning during the observation period.

No Intervention group

Description:

Participants will not receive ETT suctioning during the observation periood.