The Effects of Epidural Anesthesia on the Bioavailability of Nitric Oxide and Renal Function in Patients Undergoing Laparoscopic Surgery

Yonsei University

Status: Completed

Conditions: Prostate Cancer

Treatments: Procedure: Epidural anesthesia

Study type: Interventional

Funder types: Other

Identifiers

NCT01325844

4-2010-0537

Details and patient eligibility

About

This study was designed to investigate the effects of epidural anesthesia combined with general anesthesia during laparoscopic surgery. The investigators hypothesized that epidural anesthesia will effectively block the activation of the sympathetic nervous system during surgery, thus activating nitric oxide and reducing splanchnic ischemia and decrease in postoperative renal function.

Enrollment: 45 patients

Sex: Male

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA class 1 or 2 adult patients scheduled for endoscopic prostatectomy

Exclusion criteria

• Patient refusal
• Patients on diuretics
• Patients with renal failure (eGFR < 60 ml/min/1.73 m2)

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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45 participants in 2 patient groups

G group

No Intervention group

Description:

G group = General anesthesia group

G+E group

Experimental group

Description:

G+E group = General anesthesia + epidural anesthesia group

Treatment:

Procedure: Epidural anesthesia