The Effects of Ethanol on Intestinal Permeability and Gut Hormones

University of Copenhagen

Status: Completed

Conditions: Insulin Resistance; Ethanol; Incretin Effect

Treatments: Other: Ethanol

Study type: Interventional

Funder types: Other

Identifiers

NCT03348371

AlcoGut

Details and patient eligibility

About

The aime of this study is to envsitigate if ethanol has an incretin effect. This is done by administration of ethanol orally vs. an isoethanolaemic i.v. infusion of ethanol.

Enrollment: 12 patients

Sex: Male

Ages: 20 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Caucasian male between 20 and 50 years of age
• Body mass index (BMI) between 19 and 25 kg/m2
• Weekly alcohol intake of less than 14 units of alcohol (of 12 g)
• Normal fasting plasma glucose concentration (i.e. <6 mmol/l) and normal glycated haemoglobin A1c (HbA1c) (i.e. ≤42 mmol/mol)
• Normal haemoglobin
• Informed consent

Exclusion criteria

• First-degree relatives with diabetes and/or liver disease
• Liver disease or other alcohol-related diseases, diabetes mellitus
• Liver disease (serum ALAT and/or serum ASAT >2 × normal values)
• Nephropathy (serum creatinine above normal range and/or albuminuria)

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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12 participants in 2 patient groups

Oral day

Experimental group

Description:

Participant receive ethanol orally

Treatment:

Other: Ethanol

i.v. infusion day

Experimental group

Description:

Participant receive ethanol in an i.v. infusion

Treatment:

Other: Ethanol