The Effects of Exercise in End-stage Renal Disease Patients Undergoing Hemodialysis (EESRDS)

Universidade Estadual Paulista Júlio de Mesquita Filho

Status: Completed

Conditions: End Stage Renal Failure on Dialysis

Treatments: Other: Progressive resistance training; Other: Placebo training; Other: Aerobic training

Study type: Interventional

Funder types: Other

Identifiers

NCT02621918

CAAE-02564112.2.0000.5423

Details and patient eligibility

About

We aimed to investigate the effect of a progressive resistance training and aerobic training protocol on functional capacity, body composition and quality of life.

Full description

Subjects were randomized into group A and B: group A (n=30) exercised for the first 6 months while group B (n=31) performed a placebo exercise initially (3 months) and cross-over to aerobic exercised for 3 months more.

Enrollment: 61 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• older than 18 years
• more than three months of hemodialysis vintage
• under the permission of their nephrologist
• agreement to be randomly assigned and undergo study protocols

Exclusion criteria

• Patients in wheelchair, presenting disability, or those who had amputation and malformation of the lower limbs, causing impaired walking
• presenting representative blindness

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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61 participants in 3 patient groups, including a placebo group

Progressive Resistance Training (PRT)

Experimental group

Description:

For the progressive resistance training we use 11 exercises. The exercises for upper limbs were held in the waiting room before the hemodialysis session. Resistance exercise was carried out in two sets of 15-20 repetitions, the intensity were determined by the method of maximal repetitions, where series were run until exhaustion to momentary exercises (15-20 repetitions) with specific load. The load adjustments or volume were managed when necessary, but necessarily for every 4th week of training. The effort perception should be situated between 12 and 16 on the Borg scale (Borg and Noble, 1974), as proposed by The Life Options Rehabilitation Advisory Council: Exercise for the Patient Dialysis (1995).

Treatment:

Other: Progressive resistance training

Aerobic Exercise (AER)

Experimental group

Description:

Aerobic exercise was conducted with a mini ergometer cycling (Mini Bike E5 Acte Sports) attached to the patient chair. Patients exercised 50-60 minutes of continuous workout with increased load. The workload was adjusted when necessary, according to the perceived effort made by the patient. The scale of perceived exertion, Borg scale (Borg and Noble , 1974), was used in accordance with the proposed By The Life Options Rehabilitation Advisory Council: Exercise for the Patient Dialysis (1995), which defines the values of perceived exertion between 12 and 16.

Treatment:

Other: Aerobic training

NEPLA

Placebo Comparator group

Description:

The control group performed active mobilization of members, circumduction of cervical, scapular girdle and extremities, breathing exercises with no loads, set on three to five repetitions only and no stretch exercises. The exercises were performed during the hemodialysis session, three times per week and did not exceed 5 minutes.

Treatment:

Other: Placebo training