The Effects of Exercise on Some Biochemical Parameters in Patients With Rheumatoid Arthritis

Gazi University

Status: Unknown

Conditions: Rheumatoid Arthritis

Treatments: Other: Aerobic exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT04439682

97132852/050.01.04/

Details and patient eligibility

About

Background: RA may progress with articular and non-articular involvement.Depression prevelance is found to increase for RA patients according to healthy population and to be correlated with pain, decreased quality of life, fatigue and physical disability.BDNF level was found significantly lower in RA patients with depression. Aim of this study is to investigate the variation of BDNF, VEGF, TNF- α, IL-6, IL-1β, irisin and α- Klotho levels following acute exercise.

Methods: This study included 45 RA patients and 45 age and sex matched healthy controls. Blood samples from all subjects were taken and centrifuged before and immediately after the exercise intervention.

Enrollment: 90 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients who were aged between 18-65 years,
• Patients who got diagnosed according to American College of Rheumatology criteria
• Patients who were being followed at Firat University Department of Rheumatology

Exclusion criteria

• Patients who had regular exercise habits, malignancy, pregnancy, incorporation,
• Patients who took anti-TNF treatment
• Patients who had changes of medical treatment in last 3 months
• Patients who diagnosed with Fibromyalgia Syndrome and Osteoarthritis for lower extremity
• Patients who had cardiac symptoms according to New York Heart Association
• Patients who had dysfunction that can prevent physical activity

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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90 participants in 2 patient groups

Study group

Experimental group

Description:

Aerobic exercise will be performed for a single session

Treatment:

Other: Aerobic exercise

Control group

Active Comparator group

Description:

Aerobic exercise will be performed to healthy population for a single session

Treatment:

Other: Aerobic exercise