The Effects of Exercise Training in Vascular Function of Patients Living With HIV

Instituto Nacional de Cardiologia de Laranjeiras

Status: Completed

Conditions: HIV/AIDS

Treatments: Behavioral: Exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT03343522

CAAE42162815.5.0000.5272

Details and patient eligibility

About

Introduction: It is well known that the infection caused by the Human Immunodeficiency Virus (HIV) is associated to a higher cardiovascular event risk. On the other hand, it is clear that the aerobic exercise training induces improvements in autonomic control and vascular function, through increases in vasodilator agents and blood vessels number. However, the investigators could not find previous works that studied the microvascular function in response to exercise training in HIV patients.

Objectives: To study the impact of aerobic exercise training in endothelial function of HIV patients. In addition, the investigators will verify the association of the physical fitness to the nitric oxide bioavailability, angiogenesis and lipid profile in HIV patients.

Methods: The study subjects will be composed by HIV patients, that will be randomly divided in two different groups: exercised and sedentary. The subjects will be tested before and after training in regards to endothelial function, nitric oxide bioavailability, physical fitness and lipid profile, through flowmetry, colorimetric essays, maximal cardiopulmonary exercise test, and biochemical tests; respectively. The exercise training will be performed in a treadmill for 12 weeks, 3 times a week, 40 minutes each section.

Expected Results: The investigators expect to achieve markers that will help in understanding the interaction of HIV with several factors that contribute to an increased endothelial function after exercise training.

Full description

HIV-infection triggers a massive oxygen reactive species production, increasing oxidative stress and vascular complications. Despite the importance of therapeutic strategies in reducing the cardiovascular risk among HIV-infected patients (HIVP), exercise-related effects upon macro-and-microvascular endothelial function and oxidative stress in HIVP have not been previously reported.

Enrollment: 50 patients

Sex: All

Ages: 20 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• sedentarism for at least 6 months;
• diagnosis of HIV infection.

Exclusion criteria

• opportunistic diseases;
• nephropathies;
• cardiovascular diseases;
• locomotor limitations;
• liver diseases.

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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50 participants in 2 patient groups

Sedentarism

No Intervention group

Description:

Patients assigned to this arm shall not perform regular exercise training.

Exercise Training

Experimental group

Description:

Patients assigned to this arm will be enrolled in exercise training program.

Treatment:

Behavioral: Exercise