The Effects of Exogenous Ketones on Glucose Tolerance
Status and phase
Conditions
Treatments
Details and patient eligibility
About
The ketone body beta-hydroxybutyrate is produced during prolonged fasting or when endogenous carbohydrate stores are depleted and can be used as an alternative fuel source. Exogenous beta-hydroxybutyrate, in the form of a ketone monoester, is proposed to have glucose-lowering potential but this has not been adequately studied. The purpose of this study is to determine whether supplementing with an acute dose of ketone monoester can improve the glycemic response to a high carbohydrate mixed meal in young healthy individuals.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- Young healthy individuals
- Not taking any medications affecting glucose metabolism
Exclusion criteria
- Competitive endurance athlete (i.e., train specifically for cycling, triathlon or distance running and compete at a high level)
- Diagnosed with the chronic medical condition that may impact consumption of carbohydrates or supplements (e.g., diabetes, heart disease)
- Are currently using medications that may interfere with insulin sensitivity
- Adhere to a strict high-fat low-carbohydrate or ketogenic diet (within the last 3 months)
- Are currently using ketone supplements
- Unable to travel to and from the university in order to make your testing appointments.
- Unable to follow the controlled diet instructions required for the study.
- If pregnant or are planning to become pregnant during the study (if female)
Trial design
Primary purpose
Allocation
Interventional model
Masking
20 participants in 2 patient groups, including a placebo group
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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