The Effects of Fatigue on Exercise-Induced Hypoalgesia During a Dynamic Resistance Exercise

University of Central Florida

Status: Completed

Conditions: Healthy

Treatments: Other: Knee Extension Exercise; Other: Quiet Rest

Study type: Interventional

Funder types: Other

Identifiers

NCT05525403

2

Details and patient eligibility

About

The primary purpose of this study is to compare immediate changes in pain sensitivity (pressure pain threshold) during quiet rest, low fatigue exercise, and high fatigue exercise.

Full description

Participants will attend three sessions. Participants will fill out questionnaires, undergo pain sensitivity testing, and be randomly assigned to complete a high and low fatigue exercise on either the second or third session. During the exercise, participants will complete three sets of a single leg knee extension exercise with weight equivalent to 50% of their 1 repetition maximum until they report either a high or low fatigue level. Immediately before and after each set, the research team will examine immediate changes in sensitivity to pressure (pressure pain threshold).

Enrollment: 31 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Pain-free
• 18-60 years old
• Participant can appropriately perform the knee extension exercise (assessed during screening)

Exclusion criteria

• Non-English speaking
• Regular use of prescription pain medications
• Current or history of chronic pain condition
• Currently taking blood-thinning medication
• Systemic medical condition known to affect sensation, such as uncontrolled diabetes or neurological conditions
• Any contraindication to the application of ice, such as: uncontrolled hypertension (blood pressure over 140/90 mmHg), cold urticaria, cryoglobulinemia, paroxysmal cold hemoglobinuria, circulatory compromise
• Known presence of cardiovascular, pulmonary, or metabolic disease
• Current use of tobacco products
• Not physically ready to exercise without a medical exam as indicated by the Physical Activity Readiness Questionnaire Plus (PAR-Q+)
• Surgery, injury, or fracture to the lower back or lower extremity within the past 6 months

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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31 participants in 3 patient groups

Low Fatigue Exercise

Experimental group

Description:

Participants will complete a single leg knee extension exercise with weight until they report a fatigue level = 3/10 on the Borg Rating of Perceived Exertion. Participants will complete three sets.

Treatment:

Other: Knee Extension Exercise

High Fatigue Exercise

Experimental group

Description:

Participants will complete a single leg knee extension exercise with weight until they report a fatigue level = 8/10 on the Borg Rating of Perceived Exertion. Participants will complete three sets.

Treatment:

Other: Knee Extension Exercise

Quiet Rest

Active Comparator group

Description:

Participants will rest quietly for two minutes, three sets.

Treatment:

Other: Quiet Rest