The Effects of Foods on Cell Damage Study

Newcastle University

Status: Completed

Conditions: Inflammation; DNA Damage

Treatments: Dietary Supplement: White carrots; Dietary Supplement: Oat biscuits

Study type: Interventional

Funder types: Other

Identifiers

NCT02696811

VEG_01

Details and patient eligibility

About

Studies have shown that certain compounds inside vegetables can reduce the risk of cancer. Carrots in particular have an association with reduced incidence of colorectal, bladder and breast cancer. Compounds in carrots, called polyacetylenes, have been studied in isolated cells that have shown a reduction in cancer cells as well as inflammatory markers which have been associated with an increased risk of cancer. These polyacetylenes have not been well studied in the human body and it is unclear whether they are able to affect the biomarkers of health (disease) including DNA damage and inflammatory markers. The aim of this research project is to determine whether eating a portion of white carrots every day for 6 weeks can lead to a reduction in DNA damage and inflammatory markers compared to a control period of 6 weeks consuming a polyacetylene-free diet and a control food of a high fibre oat biscuit.

Enrollment: 38 patients

Sex: All

Ages: 45+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Non -smokers
• BMI between 18.5 and 30

Exclusion criteria

• smoking
• taking anti-inflammatories
• taking aspirin or aspirin-like drugs
• antibiotic use in the last 3 months
• metabolic conditions or conditions affecting the metabolism or digestion

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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38 participants in 2 patient groups, including a placebo group

Oat biscuits

Placebo Comparator group

Description:

Participants will eat 3 oat biscuits per day for 6 weeks

Treatment:

Dietary Supplement: Oat biscuits

White Carrots

Experimental group

Description:

Participants will eat 100g (cooked weight) of white carrots per day for 6 weeks

Treatment:

Dietary Supplement: White carrots