The Effects of Foods on Cell Damage Study

N

Newcastle University

Status

Completed

Conditions

Inflammation
DNA Damage

Treatments

Dietary Supplement: White carrots
Dietary Supplement: Oat biscuits

Study type

Interventional

Funder types

Other

Identifiers

NCT02696811
VEG_01

Details and patient eligibility

About

Studies have shown that certain compounds inside vegetables can reduce the risk of cancer. Carrots in particular have an association with reduced incidence of colorectal, bladder and breast cancer. Compounds in carrots, called polyacetylenes, have been studied in isolated cells that have shown a reduction in cancer cells as well as inflammatory markers which have been associated with an increased risk of cancer. These polyacetylenes have not been well studied in the human body and it is unclear whether they are able to affect the biomarkers of health (disease) including DNA damage and inflammatory markers. The aim of this research project is to determine whether eating a portion of white carrots every day for 6 weeks can lead to a reduction in DNA damage and inflammatory markers compared to a control period of 6 weeks consuming a polyacetylene-free diet and a control food of a high fibre oat biscuit.

Enrollment

38 patients

Sex

All

Ages

45+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Non -smokers
  • BMI between 18.5 and 30

Exclusion criteria

  • smoking
  • taking anti-inflammatories
  • taking aspirin or aspirin-like drugs
  • antibiotic use in the last 3 months
  • metabolic conditions or conditions affecting the metabolism or digestion

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

38 participants in 2 patient groups, including a placebo group

Oat biscuits
Placebo Comparator group
Description:
Participants will eat 3 oat biscuits per day for 6 weeks
Treatment:
Dietary Supplement: Oat biscuits
White Carrots
Experimental group
Description:
Participants will eat 100g (cooked weight) of white carrots per day for 6 weeks
Treatment:
Dietary Supplement: White carrots

Trial contacts and locations

1

Loading...

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2024 Veeva Systems