The Effects of Gabapentin and Ramosetron on Postoperative Nausea and Vomiting in Laparoscopic Gynecological Surgery (PONV)

Hallym University

Status: Unknown

Conditions: Postoperative Nausea and Vomiting

Treatments: Drug: Ramosetron; Drug: Gabapentin; Drug: Gabapentin and Ramosetron

Study type: Interventional

Funder types: Other

Identifiers

NCT02617121

HallymUMC

Details and patient eligibility

About

This study was designed to compare the effects of gabapentin and ramosetron on PONV in patients undergoing laparoscopic gynecologic surgery.

Full description

Postoperative nausea and vomiting (PONV) in the postanesthesia care unit is a common occurrence after general anesthesia. And laparoscopic gynecological surgery is associated with a high incidence of PONV. Several antiemetic agents such as dopaminergic, histaminic and 5-HT3 antagonist (including ondansetron, ramosetron, granisetron) have been used to prevent PONV. Gabapentin, anti-convulsant, has been shown to decrease PONV, as well as chemotherapy induced nausea and vomiting in recent studies, although the exact mechanism against PONV is not known. The purpose of this study was to compare the efficacy of gabapentin and ramosetron in preventing PONV in patients undergoing laparoscopic gynecological surgery.

Enrollment: 120 estimated patients

Sex: Female

Ages: 20 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with ASA physical status 1 and 2 between 20 and 65 years undergoing laparoscopic gynecological surgery with patient-controlled analgesia for postoperative pain control.

Exclusion criteria

• Pregnant women
• Patients who took sedatives, antiemetics, hypnotics, analgesics, steroid, or gabapentin
• Patients with neurological deficits
• Patients with history of drug abuse and allergy of study drugs

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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120 participants in 3 patient groups

Gabapentin

Active Comparator group

Description:

oral gabapentin 300 mg 1 hours before induction of anesthesia

Treatment:

Drug: Gabapentin

ramosetron

Active Comparator group

Description:

ramosetron 0.3 mg iv at end of surgery

Treatment:

Drug: Ramosetron

Gabapentin and ramosetron

Active Comparator group

Description:

oral gabapentin 300 mg 1 hours before induction of anesthesia ramosetron 0.3 mg iv at end of surgery

Treatment:

Drug: Gabapentin and Ramosetron