The Effects of General Anesthesia on Microcirculation of Central and Peripheral Soft Tissue: a Comparison of Inhalational and Intravenous Anesthetics

National Taiwan University

Status: Unknown

Conditions: Microcirculatory Effects of Anesthesia; Inhalation and Intravenous Anesthesia

Treatments: Drug: Sevoflurane; Drug: Propofol; Procedure: General anesthesia induction

Study type: Interventional

Funder types: Other

Identifiers

NCT02530632

201504089RIND

Details and patient eligibility

About

Effects of different general anesthetics on peripheral microcirculation.

Full description

Human keep body temperature in a narrow range by a variety of regulatory mechanism. Peripheral thermal receptors send signals to central nervous system which regulate body temperature via peripheral effectors, such as vasoconstriction, vasodilatation, shivering, sweating and etc. In patients undergoing general anesthesia, the regulatory mechanism is altered. General anesthesia changes blood distribution in the body, the metabolic rate of muscle, threshold of thermal regulation in the brain and etc, so that heat distribution and microcirculation condition will also change. In this study, near-infrared spectroscopy (NIRS) is used to measure the microcirculatory condition. NIRS is a non-invasive continuous measurement to detect tissue saturation with the method of different wavelength of near-infrared. General anesthesia with inhalational sevoflurane and intravenous propofol is separated into 2 groups. Because of different mechanism of general anesthesia of these 2 anesthetics, different physiologic response may occur. Body temperature and somatic saturation are compared in each group.

Enrollment: 100 estimated patients

Sex: Female

Ages: 20 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Breast surgeries under general anesthesia
2. BMI 18.5~30

Exclusion criteria

1. Cardiac disease
2. Lung disease
3. Renal disease
4. Neurological disease
5. Autonomic nervous system dysfunction

Trial design

100 participants in 2 patient groups

Sevoflurane anesthesia

Active Comparator group

Description:

Anesthesia maintained with inhalational sevoflurane

Treatment:

Procedure: General anesthesia induction

Drug: Sevoflurane

Propofol anesthesia

Experimental group

Description:

Anesthesia maintained with intravenous propofol continuous infusion

Treatment:

Drug: Propofol

Procedure: General anesthesia induction