The Effects of High-Intensity Exercise on Biological Age

Loma Linda University (LLU)

Status: Completed

Conditions: Exercise

Treatments: Other: Exercise; Other: Non Exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT05156918

5210437

Details and patient eligibility

About

The purpose of this graduate student research study is to determine if a high-intensity exercise program can slow or reverse biological (transcriptomic) aging and shed light on the underlying transcriptomic pathways involved.

Full description

24 males and 24 females will be randomly assigned to either the control group or the exercise group. Baseline measures will be obtained, including questionnaires (on stress, sleep, depression, activity level, and fitness), body composition measures, vital signs, and a blood draw. Control group participants will make no modifications to regular diet or exercise habits for 30 days. Exercise group participants will perform supervised high intensity exercise three times per week at the LLU department of physical therapy laboratory utilizing treadmills, stationary bicycles, and rowing machines. Results will be collected following conclusion of the 30-day study protocol.

Enrollment: 35 patients

Sex: All

Ages: 40 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Sex: Both Males and Females
2. Age: 40-65 years old
3. Physical Fitness: Below average scores on the Self report fitness questionnaire
4. Physical Activity: Low as measured by the International Physical Activity Questionnaire

Exclusion criteria

1. Prior (within the last 5 years) or current history of cardiovascular disease, stroke, unexplained weight loss, clinical depression, congestive heart failure, cancer, arrythmia, respiratory disease, or other serious medical conditions that would make exercise unsafe or prevent full participation in the exercise protocol.
2. Any self-reported significant increase or decrease in activity levels within the past thirty days.
3. Current use of the following medications: antibiotics, glucocorticoids, anticoagulants, narcotics, antiepileptic medications, antipsychotics, antidepressants, and hypoglycemic agents.
4. Current self-reported pregnancy

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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35 participants in 2 patient groups

Exercise Group

Experimental group

Description:

Exercise group participants will perform supervised high intensity exercise three times per week at the LLU department of physical therapy laboratory utilizing treadmills, stationary bicycles, and rowing machines.

Treatment:

Other: Exercise

Control Group

Active Comparator group

Description:

Control group participants will make no modifications to regular diet or exercise habits for 30 days.

Treatment:

Other: Non Exercise