The Effects of HMB, ATP, and HMB Plus ATP on Muscle Mass, Strength, and Power in Resistance Trained Athletes

Metabolic Technologies

Status: Completed

Conditions: Healthy Experienced Weight Training Males

Treatments: Dietary Supplement: Peak ATP and HMB; Dietary Supplement: ATP; Dietary Supplement: HMB; Dietary Supplement: Placebo

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT01508338

MTI2012-CS01

Details and patient eligibility

About

The purpose of this study is to

• determine the effects of 12 weeks of HMB free acid gel, ATP, and HMB free acid gel plus ATP supplementation in trained individuals during a periodized training program on skeletal muscle hypertrophy, body composition, strength, force, velocity, and peak power during loaded and unloaded vertical jumps.

Additionally, the study will determine if either supplementation protocol prevents the typical decay seen in performance following an overreaching cycle performed in the 9th and 10th weeks of the study.

Finally, the study will elucidate the mechanisms of action of supplementation on protein breakdown by analyzing serum indices of muscle damage (CK, LDH) and anabolic status (Testosterone:Cortisol ratio) as well as a urinary indicator of protein breakdown (3-methylhistidine).

We hypothesize that under these conditions that the supplementation protocols will augment skeletal muscle hypertrophy, strength, and power and that HMB will blunt increases in serum indices of muscle damage, and urinary indices of protein breakdown.

Full description

In a randomized and double blind study the subjects will consume either placebo supplements, HMB supplement, ATP supplement, or HMB plus ATP supplements for 12 weeks. While consuming the supplements the subjects will undergo an extensive resistance training program designed to train all major muscle groups. An additional overreaching training cycle during weeks 9 and 10 which will involve a high-volume, hypertrophy style training program.

Subject testing will consist of the following:

• Strength and power at weeks 0, 1, 4, 8, 9, 10, and 12
• Range of motion and muscle soreness at weeks 0, 1, 8, 9, and 10
• Body composition and muscle assessments at weeks 0, 1, 4, 8, 9, 10, and 12
• Body fat assessments at weeks 0, 4, 8, and 12
• Blood biochemical measurements at weeks 0, 1, 4, 8, 9, 10, and 12
• Urinary analysis for protein breakdown (3-methylhistidine) at 0, 1, 8, 9, and 10 weeks

Enrollment: 44 patients

Sex: Male

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Subjects must meet all of the inclusion criteria to participate in the study.

• Have 3 years minimum of free weight training experience
• Can squat a minimum of 1.5 times their bodyweight
• Can bench press a minimum equal to their bodyweight
• Can deadlift a minimum of 1.5 times their bodyweight
• Are free of musculoskeletal injuries
• Have not taken creatine or HMB supplements for 6 weeks
• Are not taking amino acid supplements
• Are not using anabolic or catabolic hormones
• Are not taking medications that may interfere with study measurements
• Are not users of tobacco products

All candidates meeting any one of the exclusion criteria will not be enrolled into the study.

• Do not have 3 years minimum of free weight training experience
• Can not squat a minimum of 1.5 times their bodyweight
• Can not bench press a minimum equal to their bodyweight
• Can not deadlift a minimum of 1.5 times their bodyweight
• Are not free of musculoskeletal injuries
• Have not taken creatine or HMB supplements in the past 6 weeks
• Are currently taking amino acid supplements
• Are using anabolic or catabolic hormones
• Are taking medications that may interfere with study measurements
• Use of tobacco products

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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44 participants in 4 patient groups, including a placebo group

Placebo

Placebo Comparator group

Treatment:

Dietary Supplement: Placebo

HMB

Experimental group

Treatment:

Dietary Supplement: HMB

ATP and HMB

Experimental group

Treatment:

Dietary Supplement: Peak ATP and HMB

ATP

Experimental group

Treatment:

Dietary Supplement: ATP