The Effects of Hydration on Gut Health and Thinking (WatUP)

U

University of Illinois at Urbana-Champaign

Status

Completed

Conditions

Cognitive Change
Dehydration
Gastrointestinal Microbiota

Treatments

Dietary Supplement: Water Intake

Study type

Interventional

Funder types

Other

Identifiers

NCT05315531
WatUP

Details and patient eligibility

About

The central hypothesis is that improving hydration through increased water consumption will change the relative abundance of mucolytic bacteria found in the stool. Therefore the specific aims are 1) to quantify intervention effects on fecal microbiota relative abundance and plasma lipopolysaccharide binding protein, 2) observe the effects of the intervention on bowel frequency and signs/symptoms of gastrointestinal stress, and 3) to investigate relations between executive function and hydration status.

Full description

A single arm 3-week hydration intervention will be employed where participants increase their water consumption to 2 (F) or 2.5(M) liters per day which is approximately 70% of the AI for daily water consumption. Pre-test and follow-up measures of fecal microbiota, urinary hydration status, cognitive function, circulating markers, and dietary intake will be assessed at baseline and at 3-week follow up via laboratory visits.

Enrollment

23 patients

Sex

All

Ages

19 to 50 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • 19-50 years of age
  • 18.5-34.49 kg/m2
  • 24-hour UOsm above 500 mOsm/kg
  • No antibiotic use over the past 3 months
  • Absence of metabolic diseases and use of diuretics
  • Agree to maintain typical diet intake (e.g., dietary fiber) patterns during intervention
  • Avoid consuming prebiotic and probiotic supplements during study participation
  • Not pregnant
  • Agree to follow the study protocol

Exclusion criteria

  • <19 or >50 years of age
  • <18.5 or >34.49 kg/m2
  • 24-hour UOsm <500 mOsm/kg
  • Antibiotic use over the past 3 months
  • Metabolic diseases and use of diuretics
  • Not agree to maintain typical diet intake (e.g., dietary fiber) patterns for the duration of the
  • intervention
  • Not agree with avoiding consuming prebiotic and probiotic supplements during study participation
  • Pregnant
  • Not agree to follow study protocol

Trial design

Primary purpose

Prevention

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

23 participants in 1 patient group

Water Intake
Experimental group
Description:
3-week intervention period during which articipants will be asked to increase their daily plain water consumption to at least 2.5 L/d of water for males and 2L/d for females.
Treatment:
Dietary Supplement: Water Intake

Trial contacts and locations

1

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Central trial contact

Naiman A Khan, PhD, RD

Data sourced from clinicaltrials.gov

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