The Effects Of I-PRF On Gingivectomy and Gingivoplasty

Saglik Bilimleri Universitesi

Status: Completed

Conditions: Wound Heal

Treatments: Other: İnjectable platelet rich fibrin; Procedure: Gingivectomy anad gingivoplasty

Study type: Interventional

Funder types: Other

Identifiers

NCT05871190

21.DUS.005

Details and patient eligibility

About

The study aims to evaluate the effects of injectable platelet-rich fibrin (I-PRF) applications on early wound healing after gingivectomy and gingivoplasty surgery. In this randomized controlled single-blind study, gingivectomy and gingivoplasty surgeries were performed on 46 patients. The postoperative I-PRF-applied surgery areas were compared with control regions. The surgical areas were stained with Mira-2 tone and evaluated in the ImageJ program. Wound healing was evaluated by using the Modified Manchester Scar (MMS) scale and Landry, Turnbull, and Howley (LTH) index. Vascular endothelial growth factor (VEGF) and fibroblast growth factor 10 (FGF-10) concentrations were assessed by enzyme-linked immunoabsorbent assay (ELISA). The seven-day Visual Analog Scale was used to assess pain level.

Considering the results found, I-PRF applications revealed positive effects on epithelial wound healing after gingivectomy and gingivoplasty operations.

Enrollment: 46 patients

Sex: All

Ages: 15 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

(a) systemically healthy patients ages 15-40 years, (b) pregnancy or lactation, (c) patients with chronic inflammatory gingival overgrowth in the mandibular and maxillary anterior area, (d) no attachment and bone loss, (e) not using immunosuppressive agents, systemic corticosteroids, chemotherapy, and/or radiotherapy drugs taken or prescribed 2 months before the study attempt, which may affect the study results, wound healing, and coagulation mechanism, and (f) patients with sufficient oral hygiene.

Exclusion criteria

(a) patients who had a history of periodontal treatment in the last 6 months, (b) smokers and alcohol users, those who used drugs that may cause gingival enlargement in the last 6 months, (c) patients with poor communication, and (d) patients who did not attend controls at designated times.

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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46 participants in 2 patient groups, including a placebo group

Test group

Active Comparator group

Description:

I-PRF is placed on the wound site after a gingivectomy with the conventional method and closed with a periodontal dressing

Treatment:

Procedure: Gingivectomy anad gingivoplasty

Other: İnjectable platelet rich fibrin

control group

Placebo Comparator group

Description:

closure of the wound site with only a periodontal dressing after a gingivectomy with the conventional method.

Treatment:

Procedure: Gingivectomy anad gingivoplasty