The Effects of Inhalational Anaesthetics in Cognitive Functions in Down Syndrome Patients

Asklepieion Voulas General Hospital

Status and phase: Completed; Phase 2

Conditions: Down Syndrome

Treatments: Drug: Sevoflurane; Drug: Desflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT02971254

8174

Details and patient eligibility

About

Recovery of the cognitive functions and recovery features after general anaesthesia in Down syndrome patients. A comparison of Sevoflurane and Desflurane.

Enrollment: 39 patients

Sex: All

Ages: 16 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists (ASA) classification I, II or III
• Down syndrome patients
• must be able to undergone general anaesthesia
• dental surgery necessity

Exclusion criteria

• severe dementia
• severe hearing, vision, speaking problems

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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39 participants in 2 patient groups

Sevoflurane group

Active Comparator group

Description:

inhalation anaesthetic Sevoflurane, 1 M.A.C. during surgery

Treatment:

Drug: Sevoflurane

Desflurane group

Active Comparator group

Description:

inhalation anaesthetic Desflurane, 1 M.A.C. during surgery

Treatment:

Drug: Desflurane