The Effects of Inspiratory Muscle Training on Endurance Performance in Trained Athletes Under Normoxic and Hypoxic Conditions: A Gender-based Comprehensive Study (RespiPerf)

University of Lausanne (UNIL)

Status: Not yet enrolling

Conditions: Hypoxia, Altitude

Treatments: Procedure: Inspiratory Muscle Training (IMT); Procedure: Normal Breathing

Study type: Interventional

Funder types: Other

Identifiers

NCT06121128

2023-01638

Details and patient eligibility

About

The POWERbreathe™ Plus: an Inspiratory Muscle Training device (IMT) with adjustable resistance.

Intervention lasts 4 weeks, with a frequency of 6 days/week, 2 series of 30 inspirations in the morning and evening.

Resistance based on 60% of the Pressure Maximal Inspiratory (PMI). Progressive increase in resistance every week.

Four laboratory visits: 2 pre-tests and 2 post-tests. Each pre- / post- test will go under normoxic and hypoxic conditions.

Measurements include Pulmonary functions (spirometry test); blood microcirculation (vascular occlusion test); gas exchanges (e.g. VO2max), cardiac parameters, heart rate variability, maximal aerobic power (incremental and time limit test)

Full description

The POWERbreathe™ Plus: an Inspiratory Muscle Training device (IMT) with adjustable resistance.

Intervention lasts 4 weeks, with a frequency of 6 days/week, 2 series of 30 inspirations in the morning and evening.

Resistance based on 60% of the Pressure Maximal Inspiratory (PMI). Progressive increase in resistance every week.

Four laboratory visits: 2 pre-tests and 2 post-tests. Each pre- / post- test will go under normoxic and hypoxic conditions.

Measurements include Pulmonary functions (spirometry test); blood microcirculation (vascular occlusion test); gas exchanges (e.g. VO2max), cardiac parameters, heart rate variability, maximal aerobic power (incremental and time limit test)

Enrollment: 48 estimated patients

Sex: All

Ages: 18 to 44 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Inclusion: endurance trained athletes between 18 and 44 years old

Exclusion criteria

cardiovascular, metabolic and respiratory diseases, smoking history, prescription medication (Two medication families are known to interfere with FC:

• Calcium channel blockers
• Beta-blockers

Two families are known to interfere during spirometry measurements:

• Inhaled beta-agonists
• Inhaled glucocorticoids)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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48 participants in 4 patient groups

Female Control Group (FCON)

Sham Comparator group

Description:

female endurance trained athletes between 18 and 44 years old

Treatment:

Procedure: Normal Breathing

Female Training Group (FTRAIN)

Experimental group

Description:

female endurance trained athletes between 18 and 44 years old

Treatment:

Procedure: Inspiratory Muscle Training (IMT)

Male Control Group (MCON)

Sham Comparator group

Description:

male endurance trained athletes between 18 and 44 years old

Treatment:

Procedure: Normal Breathing

Male Training Group (MTRAIN)

Experimental group

Description:

male endurance trained athletes between 18 and 44 years old

Treatment:

Procedure: Inspiratory Muscle Training (IMT)