The Effects of Intake of Protein From Cod Fillet and Cod Residual Material on Lipid Regulation, Glucose Regulation and Inflammation in Overweight or Obese Adults. (COD2017)

University of Bergen

Status: Completed

Conditions: Healthy; Overweight and Obesity

Treatments: Dietary Supplement: Intact cod protein from residual material; Dietary Supplement: Control; Dietary Supplement: Intact cod protein from fillet

Study type: Interventional

Funder types: Other

Identifiers

NCT03538821

2015/75 part 1

Details and patient eligibility

About

A high intake of fish is associated with positive health effects, including prevention and treatment of chronic non-communicable diseases, such as cardiovascular diseases (CVDs) and type 2 diabetes. These health effects have traditionally been attributed to the omega-3 fatty acids in fatty fish, but recent studies have suggested that also fish proteins may improve biomarkers of metabolic disease. Intake of cod fillet have previously shown beneficial effects on blood lipids, glucose regulation and body composition in adults with overweight or obesity. Health effect of cod residual material from fillet production (i.e., head, backbone, skin, cutoffs and entrails) have so far not been investigated, but residuals from other fish species have shown promising effects on glucose regulation in rats. The main aim of the current study is to investigate the effects of protein from cod fillet and cod residuals on serum lipids, glucose regulation and inflammatory markers in healthy overweight or obese adults.

Enrollment: 100 estimated patients

Sex: All

Ages: 20 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI ≥ 27 kg/m2
• Fasting blood glucose ≤7 mmol/L
• Physically inactive
• Percent body fat > 25 % for men and > 35 % for women

Exclusion criteria

• Allergies towards fish, milk, egg, gluten
• Tobacco use > 10 cigarettes (or snus) per day
• Diseases affecting the heart, intestinal function, kidney function or insulin secretion
• Medications targeting cholesterol -or glucose metabolism, hypertension
• Use of dietary supplements
• Pregnancy or lactation

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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100 participants in 3 patient groups

Intact cod protein from fillet

Experimental group

Description:

Dietary supplement: intact cod protein from fillet, 8 g protein daily for 8 weeks

Treatment:

Dietary Supplement: Intact cod protein from fillet

Intact cod protein from residual material

Experimental group

Description:

Dietary supplement: intact cod protein from residual material, 8 g protein daily for 8 weeks

Treatment:

Dietary Supplement: Intact cod protein from residual material

Control

Experimental group

Description:

Control group receive tablet containing fillers and no proteins

Treatment:

Dietary Supplement: Control