The Effects of Interrupting Prolonged Sitting With Intermittent Exercise on Postprandial Lipemia

The University of Texas System (UT)

Status: Completed

Conditions: Hyperinsulinism; Glucose Metabolism Disorders; Arterial Occlusive Diseases; Insulin Resistance; Cardiovascular Diseases; Metabolic Disease; Metabolic Syndrome X; Vascular Diseases; Arteriosclerosis; Atherosclerosis

Treatments: Behavioral: Prolonged sitting with interval exercise; Behavioral: Prolonged sitting without exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT03856606

2017-11-0141

Details and patient eligibility

About

The purpose of this study is to investigate the effect of interrupting prolong sedentary behavior with interval exercise on postprandial metabolism following a high fat glucose tolerance test.

Full description

All subjects complete two trials in a randomized crossover design, with each trial occurring over 4 days with a minimum of seven days between trials. The first two days of each trial serve as a control period allowing for familiarization and the control of physical activity and calorie consumption prior to the intervention. Following each control period, subjects then perform one of the interventions on Day 3. The interventions consist of either eight-hours of prolonged sitting, or eight hours of sitting interrupted every hour by five sprints lasting 4 seconds each using the interval exercise. On day 4, all subjects will undergo a high fat glucose tolerance test to determine the body's ability to clear triglycerides from the blood as well as insulin/glucose response and substrate oxidation. Blood samples will be assayed for the previously mentioned substances and postprandial gas collection will be analyzed via indirect calorimetry.

Enrollment: 8 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Exclusion criteria

• cardiovascular problems (e.g. pre-existing heart issues, coronary artery disease, hypertension, etc.)
• respiratory problems
• musculoskeletal problems that prevent prolonged sitting or exercise
• susceptibility to fainting
• Pregnancy

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

---

8 participants in 2 patient groups

Prolonged sitting without exercise

Experimental group

Description:

Subjects will be asked to undergo prolonged sitting (\~14 hours) of 1 day and will not be asked to perform interval exercise.

Treatment:

Behavioral: Prolonged sitting without exercise

Prolonged sitting with interval exercise

Experimental group

Description:

Subjects will be asked to undergo prolonged sitting (\~14 hours) of 1 day and will be asked to perform interval exercise every hour on the hour.

Treatment:

Behavioral: Prolonged sitting with interval exercise