The Effects of Intradialytic Exercise in Hemodiafiltration Patients

Chulalongkorn University

Status: Completed

Conditions: Hemodialysis; End Stage Renal Disease; Sedentary Lifestyle

Treatments: Behavioral: Intradialytic exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT03353844

139/60

Details and patient eligibility

About

Low physical activity is associated with in hemodialysis and hemodiafiltration (HDF) patients. Previous studies showed the benefits of intradialytic exercise for improvement of physical fitness and hemodialysis adequacy. However, the effect of intradialytic exercise on physical activity has not been explored. This current open-labelled randomized controlled trial is conducted in HDF patients to determine the effect of intradialytic exercise program for 6 months on daily physical activity measured by tri-axial accelerometer (wearable device).

Full description

The study is an open-labelled randomized controlled trial which compare the changes of daily physical activity measured by tri-axial accelerometer (wearable device) between the HDF patients in intradialytic exercise group and control during the 6-month period. After inclusion in to the study, all of the participants will be evaluated before randomized. The investigators will prescribe the exercise program for each participant in the exercise group. The exercise program use intradialytic cycling which will be gradually increased to at least 30 minutes with moderate intensity. The participants in control group will receive dialysis as usual without intradialytic exercise prescription. The participants will go on the program for at least 6-months period. In each session, any adverse event or side effect will be reported.

Enrollment: 12 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Dialysis vintage more than 3 months
• Sedentary or light physical activity

Exclusion criteria

• recent myocardial infarction (<12 months)
• recent ischemic stroke (<12months)
• uncontrolled comorbidities (diabetes/hypertension/heart failure/heart disease/respiratory disease)
• Life expectancy < 12 months
• active musculoskeletal problem e.g.) rheumatoid arthritis, spondyloarthropathy, osteoarthritis, fracture

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

12 participants in 2 patient groups

Intradialytic exercise group

Experimental group

Description:

These patients will get intradialytic exercise every sessions of hemodiafiltration

Treatment:

Behavioral: Intradialytic exercise

Standard dialysis group

No Intervention group

Description:

regular and standard of care in every hemodiafiltration sessions (as usual) without intradialytic exercise.