The Effects of Intraoperative Dexmedetomidine Infusion on Postoperative Bowel Movement in Patients Undergoing Laparoscopic Gastrectomy

Yonsei University

Status and phase: Completed; Phase 4

Conditions: Gastric Cancer Patients Undergoing Laparoscopic Gastrectomy

Treatments: Drug: the control group; Drug: the dexmedetomidine group

Study type: Interventional

Funder types: Other

Identifiers

NCT02164448

4-2014-0249

Details and patient eligibility

About

The investigators hypothesized that sympatholytic effect of dexmedetomidine would attenuate the hemodynamic instability and decrease in the splanchnic blood flow caused by pneumoperitoneum during laparoscopic surgery. This study is to investigate the effect of intraoperative dexmedetomidine infusion on postoperative bowel movement in patients undergoing laparoscopic gastrectomy.

Enrollment: 92 patients

Sex: All

Ages: 20 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patient between 20 and 65 of age with ASA physical status Ⅰ-Ⅲ
• gastric cancer patient undergoing laparoscopic gastrectomy

Exclusion criteria

• ASA physical status Ⅳ
• bradycardia (< 60 bpm), arrhythmia
• uncompensated heart failure
• hepatic failure (Child-Pugh score B 이상)
• renal failure (eGFR MDRD < 60 ml/min/1.73m2)

Trial design

92 participants in 2 patient groups, including a placebo group

dexmedetomidine group

Experimental group

Treatment:

Drug: the dexmedetomidine group

control group

Placebo Comparator group

Treatment:

Drug: the control group