The Effects of Intrauterine Infusion of hCG at the Time of Embryo Transfer

Mahidol University

Status: Unknown

Conditions: Infertility

Treatments: Procedure: Intrauterine hCG (pregnyl)

Study type: Interventional

Funder types: Other

Identifiers

NCT02668965

Si701/2015

Details and patient eligibility

About

The purpose of this study is to determine whether intrauterine hCG can improve the implantation rate and clinical pregnancy rate after embryo transfer in IVF/ICSI cycle.

Full description

Patients at infertility clinic, siriraj hospital who come to start IVF/ICSI treatment cycle or endometrial preparation for embryo transfer are consiferes as eligible subjects.

On the day of embryo transfer (both fresh and frozen-thaw cycle), the subjects will be randomized to 2 groups.

1. control group: embryo transfer after intrauterine infusion with standard embryo culture media 4-7 minutes
2. study group: embryo transfer after intrauterine infusion with hCG (Pregnyl) 4-7 minutes

The patients will come back for serum beta-hCG measurement 2 weeks later after embryo transfer and other 2 weeks later for transvaginal ultrasound if beta-hCG is positive.

Enrollment: 200 estimated patients

Sex: Female

Ages: 18 to 43 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. infertile women aged 18-43 years
2. indicated or willing for IVF/ICSI treatment or endometrial preparation for embryo transfer

Exclusion criteria

1. Azoospermic male partner
2. Failure to retrieve oocyte after controlled ovarian hyperstimulation
3. No embryo retrieved for transfer
4. Endometrial preparation failure

Trial design

Primary purpose: Health Services Research

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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200 participants in 2 patient groups

control

No Intervention group

Description:

intrauterine infusion with standard embryo culture media 10 microliters before embryo transfer

intrauterine hCG

Experimental group

Description:

intrauterine infusion with hCG (500 IU) 10 microliters before embryo transfer

Treatment:

Procedure: Intrauterine hCG (pregnyl)