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The Effects of Intrauterine Infusion of hCG at the Time of Embryo Transfer

M

Mahidol University

Status

Unknown

Conditions

Infertility

Treatments

Procedure: Intrauterine hCG (pregnyl)

Study type

Interventional

Funder types

Other

Identifiers

NCT02668965
Si701/2015

Details and patient eligibility

About

The purpose of this study is to determine whether intrauterine hCG can improve the implantation rate and clinical pregnancy rate after embryo transfer in IVF/ICSI cycle.

Full description

Patients at infertility clinic, siriraj hospital who come to start IVF/ICSI treatment cycle or endometrial preparation for embryo transfer are consiferes as eligible subjects.

On the day of embryo transfer (both fresh and frozen-thaw cycle), the subjects will be randomized to 2 groups.

control group: embryo transfer after intrauterine infusion with standard embryo culture media 4-7 minutes study group: embryo transfer after intrauterine infusion with hCG (Pregnyl) 4-7 minutes

The patients will come back for serum beta-hCG measurement 2 weeks later after embryo transfer and other 2 weeks later for transvaginal ultrasound if beta-hCG is positive.

Enrollment

200 estimated patients

Sex

Female

Ages

18 to 43 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  1. infertile women aged 18-43 years
  2. indicated or willing for IVF/ICSI treatment or endometrial preparation for embryo transfer

Exclusion criteria

  1. Azoospermic male partner
  2. Failure to retrieve oocyte after controlled ovarian hyperstimulation
  3. No embryo retrieved for transfer
  4. Endometrial preparation failure

Trial design

Primary purpose

Health Services Research

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

200 participants in 2 patient groups

control
No Intervention group
Description:
intrauterine infusion with standard embryo culture media 10 microliters before embryo transfer
intrauterine hCG
Experimental group
Description:
intrauterine infusion with hCG (500 IU) 10 microliters before embryo transfer
Treatment:
Procedure: Intrauterine hCG (pregnyl)

Trial contacts and locations

1

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Central trial contact

savinee boonsuk, M.D.

Data sourced from clinicaltrials.gov

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