The Effects of Intravenous Fluids on Perfusion Index and Pleth Variability Index

Tokat Gaziosmanpasa University

Status: Completed

Conditions: Perfusion

Treatments: Drug: sodium chloride; Drug: Ringer-Lactate Infusion Solution Bag; Drug: Hydroxyethylstarch

Study type: Interventional

Funder types: Other

Identifiers

NCT03048162

OMU KAEK 2016/390

Details and patient eligibility

About

This study is aimed to assess the effects of intravenously administered three fluid types on perfusion index and pulse variability index in patients during preoperative period. Patients will be randomly divided into three groups. Baseline, 5th, 10th, 15th, 20th, 25th and 30th min non-invasive blood pressure, oxygen saturation, heart rate, room temperature, perfusion index and pulse variability index will be measured and recorded.

Full description

Intravenous volume replacement alter the dynamics of microcirculation. Perfusion index and pulse variability index are the recent parameters to evaluate the tissue microcirculatory condition. This study is aimed to assess the effects of intravenously administered three fluid types on perfusion index and pulse variability index in patients during preoperative period. Patients will be taken to recovery room in the operating theatre and wait for 15 minutes to balance the skin temperature of the patients to the environment. Patients will be randomly divided into three groups using closed envelope technique as Group L (received 500 ml of Ringer's lactate), Group S (500 ml of saline) and Group H (received 500 ml of 6% hydroxyethylstarch). Baseline, 5th, 10th, 15th, 20th, 25th and 30th min non-invasive blood pressure, oxygen saturation, heart rate, room temperature, perfusion index and pulse variability index will be measured and recorded.

Enrollment: 93 patients

Sex: All

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• having a fasting period of 8 hours
• quit smoking for 8 hours before the procedure

Exclusion criteria

• not to participate in the study
• presence of peripheral vascular disease
• a history of upper extremity surgery
• presence of any kind of psychiatric disease

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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93 participants in 3 patient groups

sodium chloride

Active Comparator group

Description:

0.9% isotonic sodium chloride, 500 ml, one package in 30 minutes

Treatment:

Drug: sodium chloride

Hydroxyethylstarch

Active Comparator group

Description:

6% hydroxyethylstarch, 500 ml, one package in 30 minutes

Treatment:

Drug: Hydroxyethylstarch

Ringer-Lactate Infusion Solution Bag

Active Comparator group

Description:

Ringer's lactate, 500 ml, one package in 30 minutes

Treatment:

Drug: Ringer-Lactate Infusion Solution Bag