The Effects of L-Arabinose and D-xylose on Intestinal Sucrase Activity in Man (M192)

University of Copenhagen

Status: Completed

Conditions: Insulin Resistance

Treatments: Dietary Supplement: Placebo comparator: 0% pentose; Dietary Supplement: Active comparator: 4% D-xylose; Dietary Supplement: Active comparator: 8% D-xylose; Dietary Supplement: Active comparator: 8% L-arabinose

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT01957098

(KF) 11 324909

Details and patient eligibility

About

The purpose of this study is to investigate the effect of L-arabinose and D-xylose in a sugar-rich drink on intestinal sucrase activity in healthy volunteers by measuring postprandial blood glucose and insulin, and selected intestinal hormonal responses to increasing doses of L-arabinose and D-xylose.

Full description

Based on previous scientific results we hypotesize, that pentoses decreases the demand for insulin in metabolizing a given dose of sucrose.

Enrollment: 14 patients

Sex: Male

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy males
• BMI between 18.4-25 kg/m2
• age between 18 and 30

Exclusion criteria

• donation of blood 3 months before or during the study
• gastrointestinal disorders, diabetes, hypertension, hyperlipidemia, chronic infectious disease (HIV or hepatitis)
• smoking
• consumption of more than 21 alcoholic drinks/week
• elite athletes
• on medication

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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14 participants in 4 patient groups, including a placebo group

0% pentose

Placebo Comparator group

Description:

Pure sucrose without pentoses added.

Treatment:

Dietary Supplement: Placebo comparator: 0% pentose

4% D-xylose

Active Comparator group

Description:

Sucrose drink supplemented with 4% D-xylose

Treatment:

Dietary Supplement: Active comparator: 4% D-xylose

8% D-xylose

Active Comparator group

Description:

Sucrose drink supplemented with 8% D-xylose

Treatment:

Dietary Supplement: Active comparator: 8% D-xylose

8% L-arabinose

Active Comparator group

Description:

Sucrose drink supplemented with 8% L-arabinose

Treatment:

Dietary Supplement: Active comparator: 8% L-arabinose