The Effects of L-arginine Supplementation on Anaerobic Exercise Performance

University of Manitoba

Status: Enrolling

Conditions: Human Performance; Skeletal Muscle

Treatments: Dietary Supplement: Placebo; Dietary Supplement: L-arginine

Study type: Interventional

Funder types: Other

Identifiers

NCT06475391

HE2024-0063

Details and patient eligibility

About

The purpose of this study is to evaluate if acute ingestion of L-arginine will enhance anaerobic exercise performance in young, healthy, and recreationally active adults.

Full description

After being enrolled in the study you will be measured on a number of parameters including: body circumferences, body composition via bioelectrical impedance analysis (BIA), height, weight, resting blood pressure, and resting heart rate.

All participants will be asked to complete the same protocol for this study. The study design is a randomized, double-blind, placebo controlled, cross-over type of study. What this means is that each participant in the study will complete two exercise sessions after ingesting either a placebo (dextrose - a sugar molecule) or the active ingredient [insert supplement] plus dextrose. Neither you nor the research assistant testing you on the exercise sessions will know which ingredient you are ingesting before each exercise trial (i.e., the double-blind portion of the study). We will also randomize the order of which supplement plus placebo or placebo alone you will ingest so neither you nor the research assistant testing will know this either. The cross-over part of the study is that you will complete 2 testing sessions to assess some physical performance variables (grip strength, jump height and power, and anaerobic energy system power output) with one-week of a wash-out period between them. This will allow us to compare the placebo session to the active nutritional supplement plus placebo condition to evaluate if the supplements improve exercise performance acutely.

You will also be asked to fill in a 24-hour food and fluid log for the period before your initial exercise test. Then you will be asked to repeat this food and fluid intake when completing the second session. No caffeine, alcohol, or vigorous exercise will be allowed for the 24-hours prior to each trial.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 39 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Recreationally physically active individuals will be recruited for the study. In this context it means all participants perform 1-hour of exercise per day over 3-days per week at a minimum for 1-month. All participants will be between the ages of 18-39 years of age.

Exclusion criteria

• Exclusion criteria for the study includes: 1) smokers; 2) unhealthy (have cardiovascular, metabolic, neurological, or psychological disease); 3) taking medication for any condition; 4) any known allergy to the supplements of interest (L-arginine or placebo [dextrose]).

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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20 participants in 2 patient groups, including a placebo group

L-arginine

Experimental group

Description:

Participants will ingest 2 grams of L-arginine before completing three anaerobic exercise tasks (grip strength, vertical jump, and Wingate cycle ergometer test).

Treatment:

Dietary Supplement: L-arginine

Placebo

Placebo Comparator group

Description:

Participants will ingest 2 grams of placebo (dextrose) before completing three anaerobic exercise tasks (grip strength, vertical jump, and Wingate cycle ergometer test).

Treatment:

Dietary Supplement: Placebo