The Effects of Lactobacillus Plantarum on Cortisol, IgA and Alpha-amylase Levels in Human Saliva During Stress

Lund University

Status: Completed

Conditions: Stress Reaction

Treatments: Dietary Supplement: Probiotic (Lactobacillus Plantarum); Dietary Supplement: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT02974894

Exjobb stress

Details and patient eligibility

About

In the present study the main goal has been to clarify the effect of the probiotic bacteria Lactobacillus plantarum 299v on the salivary cortisol level in young adults under examination stress. Salivary IgA from minor glands and in whole human saliva was measured as alternative marker of stress. The hypothesis was that the levels of cortisol would be reduced or stabilized in the test group in comparison to the placebo group where the cortisol levels were expected to increase due to the examination-induced stress. By contrast, the salivary IgA levels were expected to increase in the test group in comparison to the placebo group.

Enrollment: 42 patients

Sex: All

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• adults
• studying at the University in Lund
• participation in ongoing examination period

Exclusion criteria

• pregnancy
• intake of antibiotics
• medication with cortisone during the study period

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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42 participants in 2 patient groups, including a placebo group

Probiotic

Experimental group

Description:

Capsules containing potato starch as a filler and Lactobacillus plantarum

Treatment:

Dietary Supplement: Probiotic (Lactobacillus Plantarum)

Placebo

Placebo Comparator group

Description:

Capsules containing potato starch

Treatment:

Dietary Supplement: Placebo