The Effects of Linezolid and Vancomycin on Inflammation and Cellular Signaling Vents

Utah System of Higher Education (USHE)

Status: Completed

Conditions: Sepsis

Treatments: Drug: Linezolid or Vancomycin

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT00811980

Pfizer GA5951WK

00392

Details and patient eligibility

About

We will determine if linezolid inhibits cellular activation and production of pro-inflammatory cytokines, providing mechanistic rationale for its clinical efficacy and the justification for further investigations in S. Aureus sepsis.

Enrollment: 60 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy, taking no medications, and not recently hospitalized

Exclusion criteria

• Infection (active)

Trial design

60 participants in 1 patient group

Heathy Subjects

Treatment:

Drug: Linezolid or Vancomycin