The Effects of Local Infiltration Versus Epidural Following Liver Resection 2 (LIVER 2)

University of Edinburgh

Status: Completed

Conditions: Open Liver Resection

Treatments: Device: Wound catheter; Device: Epidural

Study type: Interventional

Funder types: Other

Identifiers

NCT01747122

2012/R/SU/01 - LIVER 2 Trial

Details and patient eligibility

About

The investigators plan to compare epidurals versus wound catheters for effects on pain relief and recovery following open liver surgery.

Enrollment: 97 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing open hepatic resection for benign or malignant conditions.

Exclusion criteria

• Patients with contraindication to either epidural or wound catheter techniques.
• Inability to give written, informed consent.
• Jaundice (Bilirubin > 100 μmol/L)
• Liver resection combined with secondary surgical procedure.
• Age < 18 years
• Pregnant women
• patients on long term opiates for chronic pain

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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97 participants in 2 patient groups

Wound catheter

Experimental group

Description:

Wound catheter

Treatment:

Device: Wound catheter

Epidural

Active Comparator group

Description:

Standard epidural, pre-operative insertion, to be run for 48 hours

Treatment:

Device: Epidural