The Effects of Losartan on Emotion Processing

University of Electronic Science and Technology of China

Status: Unknown

Conditions: Healthy

Treatments: Drug: Placebo Oral Tablet; Drug: Losartan

Study type: Interventional

Funder types: Other

Identifiers

NCT04606212

UESTC-neuSCAN-73

Details and patient eligibility

About

The aim of the study is to investigate the effect of losartan (50mg, single dose) on salience processing

Full description

In a double-blind, between-subject, placebo-controlled design the effects of a single dose of losartan (50mg) on salience processing in healthy participants will be examined. The study will adopt a previously validated visual Oddball fMRI paradigm, starting 90 minutes after subjects receive 50mg losartan or placebo. The task requires participants to respond to emotional and novelty oddballs. Neural activity will be assessed by the acquisition of functional magnetic resonance imaging (fMRI) data.

Enrollment: 90 estimated patients

Sex: All

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy subjects without past or current psychiatric or neurological disorders

Exclusion criteria

• history of head injury
• medical or psychiatric illness
• hypertension

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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90 participants in 2 patient groups, including a placebo group

Losartan group

Experimental group

Treatment:

Drug: Losartan

Placebo group

Placebo Comparator group

Treatment:

Drug: Placebo Oral Tablet