The Effects of Losartan on Social Reward

University of Electronic Science and Technology of China

Status: Unknown

Conditions: Healthy

Treatments: Drug: Losartan; Drug: Placebo Oral Tablet

Study type: Interventional

Funder types: Other

Identifiers

NCT04604756

UESTC-neuSCAN-72

Details and patient eligibility

About

The aim of the study is to investigate the effect of losartan (50mg, single dose) on social reward

Full description

In a double-blind, between-subject, placebo-controlled design the effects of a single dose of losartan (50mg) on social reward in healthy participants will be examined. 90 minutes after subjects administrate 50mg losartan or placebo, participants will undergo a social incentive delay task. Neural activity will be assessed by the acquisition of functional magnetic resonance imaging (fMRI) data.

Enrollment: 90 estimated patients

Sex: All

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy subjects without past or current psychiatric or neurological disorders

Exclusion criteria

• history of head injury
• medical or psychiatric illness
• hypertension

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

90 participants in 2 patient groups, including a placebo group

Losartan group

Experimental group

Description:

Drug: Losartan

Treatment:

Drug: Losartan

Placebo group

Placebo Comparator group

Description:

Drug: Placebo Oral Tablet

Treatment:

Drug: Placebo Oral Tablet