The Effects of Low-dose Atropine and Orthokeratology in Pediatric Myopia Control (AVO)

Evidence Based Cataract Study Group

Status: Enrolling

Conditions: Myopia

Treatments: Drug: low-dose atropine eye drops; Device: orthokeratology

Study type: Interventional

Funder types: Other

Identifiers

NCT05478356

EvidenceBCSG

Details and patient eligibility

About

Both orthokeratology and atropine eye drops are effective methods for myopia control, but few studies have compared them all together simultaneously. Therefore, the primary aim of the present study was to compare the effect of orthokeratology versus low-dose (0.01% and 0.02%) atropine on the control of myopia progression.

Enrollment: 100 estimated patients

Sex: All

Ages: 8 to 18 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Best corrected visual acuity less then 0.00 log MAR (minimum angle of resolution) units Cycloplegic SER of - 1.0 D or less in both eyes. An inter-eye cycloplegic SER difference of 1.00 D or more.

Exclusion criteria

Children with cycloplegic cylinder refraction of more than + 1.00 D or less than - 1.00 D.

History of binocular vision problems, including strabismus. History of known ocular disorders, including media opacities, macular dysgenesis, optic nerve hypoplasia, perinatal brain injury, buphthalmos, and retinopathy of prematurity.

History of medication use that might have affected the refractive results. Systemic or developmental problems that might have hindered refractive development.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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100 participants in 2 patient groups

orthokeratology group

Experimental group

Treatment:

Device: orthokeratology

low-dose atropine group

Active Comparator group

Treatment:

Drug: low-dose atropine eye drops