The Effects of Marijuana on Orientation and Motor Coordination and Brain Metabolism in Regular Smokers of Marijuana

Tel Aviv Sourasky Medical Center

Status: Completed

Conditions: Marijuana Dependence

Treatments: Drug: Tetra Hydro Cannabinol (THC)

Study type: Interventional

Funder types: Other

Identifiers

NCT00270803

TASMC-05-EE-03-124-CTIL

Details and patient eligibility

About

This study investigates the effects of 17mg and 13mg Delta THC on orientation and motor coordination and brain metabolic activity in regular users of marijuana. Subjects were tested twice, after smoking cigarettes with marijuana and after smoking cigarettes without marijuana.On both occasions they performed on a virtual reality maze task. They were afterwards scanned in Positron Emission Tomography (PET) with Fluoro-deoxy-glucose (FDG).

Full description

This study investigates the effects of 17mg and 13mg Delta THC on orientation and motor coordination and brain metabolic activity in regular users of marijuana. Subjects were tested twice, after smoking cigarettes with marijuana and after smoking cigarettes without marijuana. On both occasions they performed on a virtual reality maze task. They were afterwards scanned in Positron Emission Tomography (PET) with Fluoro-deoxy-glucose (FDG). 12 subjects were tested so far on both conditions.

Enrollment: 12 patients

Sex: All

Ages: 20 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Marijuana dependence
• Age 20-65
• Male and female

Exclusion criteria

• Pregnant women
• Dependence on other substances
• Psychiatric diagnosis apart from marijuana dependence
• Neurological disorder
• Young persons

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: Quadruple Blind

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12 participants in 1 patient group, including a placebo group

A

Placebo Comparator group

Description:

Low nicotine cigarettes without THC

Treatment:

Drug: Tetra Hydro Cannabinol (THC)