The Effects of Miminal Stimulation Protocol on Preimplantation Genetic Screening

Gokalp Oner

Status: Unknown

Conditions: Preimplantation Genetic Screening

Treatments: Genetic: protocol

Study type: Observational

Funder types: Other

Identifiers

NCT05220995

31.01.2022

Details and patient eligibility

About

PGS has been the most effective method for embryo selection in IVF cycles. Euploidy rates decrease significantly with advancing maternal age (AMA). The dosage of gonadotropins also may be increased to recruit an adequate number of follicles in AMA women, minimal Stimulation Protocol (MSP) with the new combination of human menopausal gonadotrophin (hMG) and clomiphene citrate (CC) for controlled ovarian hyperstimulation is defined for poor ovarian response women. The aim of this study is to show minimal stimulation protocol affect euploidy and pregnancy rates in preimplatation genetic screening (PGS) cycles with single embryo transfer.

Enrollment: 200 estimated patients

Sex: Female

Ages: 38 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria: Advanced maternal aged -

Exclusion Criteria: Severe male factor, endometriosis, and absolute tubal factor were excluded in this study.

Trial design

200 participants in 2 patient groups

100 patients with minimal

Description:

In advancing maternal age (AMA) women, minimal stimulation protocol (MSP) with the new combination of human menopausal gonadotrophin (hMG) and clomiphene citrate (CC) were performed for controlled ovarian hyperstimulation is defined for poor ovarian response women.

Treatment:

Genetic: protocol

100 patients with recombinant FSH antagonist protocol

Description:

In advancing maternal age (AMA) women, flexible antagonist protocol with recombinant FSH were performed for controlled ovarian hyperstimulation is defined for poor ovarian response women.

Treatment:

Genetic: protocol