The Effects of Mood on Cerebral Perfusion

University Ghent

Status: Completed

Conditions: Cerebral Perfusion

Treatments: Behavioral: Mood induction (using own memories); Device: Arterial spin labeling MRI; Device: Physiological monitoring

Study type: Interventional

Funder types: Other

Identifiers

NCT03302130

EC/2015/0528

Details and patient eligibility

About

Measuring brain perfusion is biased by a inter- and intrasubject variability, caused by physiological and lifestyle factors. In this study, the investigators want to investigate the effects of a different mood state (neutral, positive and negative mood), induced using subjects own memories, on both global and regional cerebral perfusion, measured with arterial spin labeling.

Enrollment: 48 patients

Sex: All

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy university students
• between 18 and 30 years old

Exclusion criteria

• No informed consent
• Not using hormonal contraception
• MRI-contraindications
• Claustrophobia
• Pregnancy
• Chronic diseases and chronic medication use

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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48 participants in 1 patient group

Imaging healthy volunteers

Experimental group

Description:

Mood induction: positive, negative, neutral mood (using subjects own memories) Arterial spin labeling MRI Physiological monitoring

Treatment:

Device: Physiological monitoring

Device: Arterial spin labeling MRI

Behavioral: Mood induction (using own memories)