The Effects of Morphine on Desflurane Consumption and Recovery Time

Baskent University

Status and phase: Completed; Phase 4

Conditions: Abdominal Hysterectomy (& Wertheim)

Treatments: Drug: Morphine

Study type: Interventional

Funder types: Other

Identifiers

NCT02362022

14.09.2007/88-4

Details and patient eligibility

About

Combination of volatile and opioid agents are used to achieve unconsciousness, haemodynamic stability and analgesia for surgical prosedures. This prospective, randomized, double-blind, controlled study evaluates the effects of two different doses of morphine sulphate (0.1 mg/kg and 0.2 mg/kg), on desflurane consumption, recovery characteristics, postoperative analgesic requirements and side effects during total abdominal hysterectomy.

Enrollment: 90 patients

Sex: Female

Ages: 40 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• undergoing total abdominal hysterectomy with general anaesthesia

Exclusion criteria

• renal dysfunction (cre>1.2), liver failure, cardiovascular, psychiatric, allergic and metabolic disorders

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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90 participants in 3 patient groups, including a placebo group

Group Saline

Placebo Comparator group

Description:

Group Saline (Group S) received i.v saline 0.9 % in 10 ml volume (n=30)

Treatment:

Drug: Morphine

Group Morphine 1

Active Comparator group

Description:

Group Morphine 1 (Group M1) received i.v morphine 0.1 mg kg-1, in 10 ml volume (n=30)

Treatment:

Drug: Morphine

Group Morphine 2

Active Comparator group

Description:

Group Morphine 2 (Group M2) received i.v morphine 0.2 mg kg-1, in 10 ml volume (n=30)

Treatment:

Drug: Morphine