The Effects of Music Therapy on Near-infrared Spectroscopy and Electroencephalogram in Premature Infants

Fudan University

Status: Completed

Conditions: Near-infrared Spectroscopy; Music; Preterm Infant; Electroencephalogram

Treatments: Other: music

Study type: Interventional

Funder types: Other

Identifiers

NCT04009655

MTOBF

Details and patient eligibility

About

Music has been consistently shown magic power in brain plasticity. Several study proved music can influence electronic activity of preterm infants' brain, while none study covered region oxygen metabolic. The investigators aim to discover the effects of music therapy on near-infrared spectroscopy and electroencephalogram in premature infants.

Full description

Previous studies of music therapy have made some achievements for adult Parkinson's disease, schizophrenia, depression, anxiety, post-traumatic stress and pediatric autism spectrum disorders. For newborns, studies mainly focused on the effects of basic vital signs, feeding and pain score decreasing. So far, no studies evaluating the effect of music therapy on brain oxygen metabolic and electronic activity.

Enrollment: 45 patients

Sex: All

Ages: 224 to 258 days old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Postmenstrual age of 32-36+6 weeks.
• Appropriate weight for gestational age.
• To have signed an informed consent to participate in the study.
• Have reached clinical stability.

Exclusion criteria

• Have nervous system diseases or obvious nervous system symptoms.
• Severe congenital diseases.
• The maintenance of sedative or analgesic drugs.
• Support with mechanical ventilation.

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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45 participants in 2 patient groups

music therapy

Experimental group

Description:

The infant will receive music therapy over 3 consecutive days and will obtain standard care as usual

Treatment:

Other: music

control

No Intervention group

Description:

The infant does not receive any sound emission because the headphone will be turned off and will obtain standard care as experimental