The Effects of n-3 LCPUFAs in Patients With Colorectal Cancer

University of Copenhagen

Status and phase: Completed; Phase 4

Conditions: Quality of Life; Cancer Cachexia; Side Effects

Treatments: Dietary Supplement: Placebo; Dietary Supplement: Fish Oil

Study type: Interventional

Funder types: Other

Identifiers

NCT04699760

H-4-2014-131

Details and patient eligibility

About

The aim of this study is to determine the effects of n-3 PUFAs on weight, physical funktion and quality of life in patients with colorectal cancer.

Full description

Primary outcomes:

• Weight
• Physical function
• Hand-grip strength

Secondary outcomes:

• Quality of life
• Mid-upperarm circumference
• Incorporation of n-3 PUFAs into cell membranes

Enrollment: 50 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ≥18 years
• Patients with diagnosed colorectal cancer with metastases treated with chemotherapy on Rigshospitalet, Copenhagen

Exclusion criteria

• < 18 years
• Patients in palliative care
• patients with haemophilia
• Patiens in treatment of anti-coagulation
• Patients with genetic hyperkolesterolemia
• Pre-dialytic patients (GFR<15ml/min/1,73m2 eller kreatinin ≥500 mmol/L)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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50 participants in 2 patient groups, including a placebo group

Placebo

Placebo Comparator group

Description:

Nutritional supplement without fish oil

Treatment:

Dietary Supplement: Placebo

Fish oil

Active Comparator group

Description:

Nutritional supplement with fish oil

Treatment:

Dietary Supplement: Fish Oil