The Effects of Nitrogen Protoxide and Oxygen on Corneal Endothelial in Pediatric Patients

Inonu University

Status: Completed

Conditions: Anesthesia; Reaction; Cornea

Treatments: Other: Nitrogen protoxide; Other: Oxygen

Study type: Interventional

Funder types: Other

Identifiers

NCT03006211

Asozkan-4

Details and patient eligibility

About

To evaluate the mean changes in Endothelial Cell and Corneal pachymetry in eyes that operated under N2O + sevoflurane and O2 + sevoflurane general anesthesia.

Full description

40 eyes of 40 patients who had extraocular surgery under general anesthesia will be included in this prospective study. Cell density, Cell variatio, Hexagonality rate and pachymetry specular microscopy results at before surgery and 1 week and 1 month after surgery will be analyzed. O2 (1 l/min) with 50% air and N2O (1 l/min) with 50% air will be applied to each group with flow rate 2 l/min totally, respectively. The duration of surgery will be recorded.

Enrollment: 40 patients

Sex: All

Ages: 5 to 12 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 40 eyes of 40 pediatric patients who had extraocular surgery under general anesthesia

Exclusion criteria

• None

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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40 participants in 2 patient groups

corneal endothal

Active Comparator group

Description:

Evaluate the effects of nitrogen protoxide to corneal endothal and compare with oxygen.

Treatment:

Other: Nitrogen protoxide

Other: Oxygen

Cell density

Active Comparator group

Description:

Evaluate the effects of nitrogen protoxide to Cell density and compare with oxygen.

Treatment:

Other: Nitrogen protoxide

Other: Oxygen