The Effects of Omega 3 and Vitamin E Supplementation on the Serum Antioxidant Enzymes and Gene Expressions of PGC-1a, h TERT, FOXOs and SIRTs in CAD Patients

Tehran University of Medical Sciences

Status and phase: Unknown; Phase 4

Conditions: Coronary Artery Disease

Treatments: Dietary Supplement: placebo of omega 3; Dietary Supplement: omega 3; Dietary Supplement: vitamin E; Dietary Supplement: placebo of vitamin E

Study type: Interventional

Funder types: Other

Identifiers

NCT02011906

95983

Details and patient eligibility

About

The aim of this study is to determine the effects of omega 3 supplementation and its concurrent supplementation with vitamin E on the serum levels of antioxidant enzymes and the expressions of the PGC-1a, h TERT, FOXO1, FOXO3a , SIRT1,SIRT3, SIRT6 genes in PBMC cells in the patients with coronary artery disease

Enrollment: 20 estimated patients

Sex: Male

Ages: 45 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

literate, willingness to participation, CAD patients 45- 65 years old, body mass index< 30, avoidance of dietary supplements, vitamins and herbal products at least 3 months before and throughout the intervention, willing to maintain body weight during the study

Exclusion criteria

• people who have used vitamin E or omega 3 supplements in last 3 months, having chronic renal disease ,cancer, Hepatobilliary diseases, hematological disorders, hypo- or hyperthyroidism, diabetes, treatment with PPAR-gamma agonists or Thiazolidinediones, Smokers

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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20 participants in 3 patient groups, including a placebo group

CAD, OMEGA 3

Active Comparator group

Description:

patients with CAD who receive 4 gr/day omega 3 in the form of 4 softgels each of them contains 1000 mg omega 3 and a softgel contains placebo of vitamin E

Treatment:

Dietary Supplement: omega 3

Dietary Supplement: placebo of vitamin E

CAD, omega 3 and vitamin E

Active Comparator group

Description:

patients with CAD who receive 4 gr/day omega 3 in the form of 4 softgels each of them contains 1000 mg omega 3 and a softgel contains 400 IU vitamin E

Treatment:

Dietary Supplement: omega 3

Dietary Supplement: vitamin E

CAD, placebo

Placebo Comparator group

Description:

patients with CAD who receive 4 softgels/day each of them contains placebo of omega 3 and a softgel/day contains placebo of vitamin E

Treatment:

Dietary Supplement: placebo of omega 3

Dietary Supplement: placebo of vitamin E