The Effects of Optimizing Post-operative Pain Management With Multi Modal Analgesia on Immune Suppression and Oncologic Outcome in Patients Undergoing Laparoscopic Colorectal Surgery

Yonsei University

Status: Withdrawn

Conditions: Laparoscopic Colorectal Resection Due to Cancer

Treatments: Drug: IV PCA only apply; Drug: IV ketamine/lidocaine/IV PCA apply

Study type: Interventional

Funder types: Other

Identifiers

NCT03462836

4-2017-0773

Details and patient eligibility

About

Traditionally, pain control methods based on narcotic analgesics have been used to control severe pain after surgery, but this has resulted in side effects such as vomiting, constipation, dizziness, mental confusion due to drugs, and respiratory depression. This slowed the recovery of the patient after surgery and increased the duration of hospitalization, which had a negative impact on the patient 's prognosis. In addition, research has been conducted on the use of various painkillers in a variety of ways over the past decade to reduce the dose of narcotic analgesics and to increase the effectiveness of pain control, since studies of anesthetics and narcotic analgesics have shown immunosuppressive effects.

This study investigate the effect of multimodal analgesics for postoperative pain control on immune function amd prognosis in patients undergoing laparoscopic colorectal cancer resection.

Sex: All

Ages: 20 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. elective laparoscopic colorectal resection due to colorectal cancer
2. curative, resectable operation
3. ASA classification Ⅰ-Ⅲ

Exclusion criteria

1. elective co-operation due to distance metastasis
2. preoperative chemo/radiation therapy
3. drug allergy to opioid, tramadol, local anesthetics
4. MAOi medication (within 14 days of surgery)
5. decreased hepatic/renal function
6. Patients who can not read the consent form or are not fluent in Korean (illiterate, foreigner
7. pregnant, lactating women
8. palliative surgery

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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0 participants in 2 patient groups

IV ketamine/lidocaine/IV PCA (MA) group

Experimental group

Description:

In addition to basic anesthetic methods, multimodal analgesia with IV ketamine, lidocaine and IV PCA apply

Treatment:

Drug: IV ketamine/lidocaine/IV PCA apply

IV PCA only (CA) group

Active Comparator group

Description:

In addition to basic anesthetic methods, only IC PCA apply for pain control

Treatment:

Drug: IV PCA only apply