The Effects of PaCO2 Levels on Cerebral Metabolism and Perfusion During Induced Hypothermia.

Tampere University Hospital

Status: Completed

Conditions: Cerebral Metabolism and Perfusion

Treatments: Other: mild hypo- and hyperventilation

Study type: Interventional

Funder types: Other

Identifiers

NCT00766103

R06213

Details and patient eligibility

About

Incidence of hypo- and hypercarbia during induced hypothermia after cardiac arrest is high. The original report from HACA-group reported that hypothermia treated patients had improved survival and neurological outcome. Suprisingly, in that trial normocarbia was not achieved even though the aim was set for ventilatory support as normoventilation. This study aims to investigate the effects of mild hypo- and hypercarbia on cerebral perfusion (blood flow, intracranial pressure) and metabolism (microdialysate metabolites). We hypothesize that uncontrolled ventilatory suppport may render the patients in risk of exacerbation of neuronal damage, conversely, further improvement in outcome may be achieved with succesfull ventilatory management. We intend to enroll 10 out-of-hospital cardiac arrest patients succesfully resuscitated and subsequently treated with controlled hypothermia for 24 hours. The patients in need of anticoagulation are excluded. We plan to induce mild hypocarbia and hypercarbia during and after induced hypothermia. Metabolic and perfusion data are collected with clinically used methods such as transcranial doppler, intracranial pressure measurement, near infrared spectroscopy, jugular bulb, intracerebral microdialysis).

Enrollment: 8 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

succesfull resuscitation of out of hospital cardiac arrest, primary rhytm shockable

Exclusion criteria

• known coagulopathy, need of anticoagulation therapy, need of interventional cardiological procedures

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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8 participants in 1 patient group

crossover: hypo- and hypercarbia

Other group

Treatment:

Other: mild hypo- and hyperventilation