The Effects of Pain and Pain Relief on Peripheral Nerve Excitability

University of Aarhus

Status: Enrolling

Conditions: Analgesia

Treatments: Device: Heat Stimulation

Study type: Observational

Funder types: Other

Identifiers

NCT06356376

UAarhus_AGK_MNG_2

Details and patient eligibility

About

This study will assess changes in nerve excitability of C-fibers, and changes in sympathetic or parasympathetic tone, when the subject experiences pain and pain relief.

The investigators will continuously measure blood pressure, heart rate, respiration rate, gastric motility, sympathetic skin response and C-fiber excitability while using thermal stimuli before and after an analgesic.

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy Participants able to give informed consent.

Exclusion criteria

• Chronic pain conditions
• Neurological or Psychiatric disease
• Other major diseases
• Pain medication within the last 24 hours

Trial design

30 participants in 1 patient group

Healthy Participants

Treatment:

Device: Heat Stimulation